David C Gemperline
B.A. in Chemistry and Biology, Carthage College, Kenosha WI
Contact
My research focuses on the 26S proteasome in Arabidopsis thaliana. The 26S proteasome is a large multi-protein, multi-subunit complex that is responsible for degrading proteins, especially those that are poly-ubiquitinated. The proteasome regulates a myriad of processes including: differentiation, growth, and environmental responses. The 26S proteasome consists of two large subunits: the 19S regulatory particle that recognizes and unfolds ubiquitinated substrates, and the 20S core protease that degrades unfolded substrates. I have a broad interest in the regulatory particle that gates proteins destined for proteolysis as well as an interest in how the proteasome complex as a whole is regulated. I am utilizing genetics, biochemistry, and proteomics to analyze the 26S proteasome in Arabidopsis.